abstract：:Despite the initially high response rate to standard front-line debulking surgery followed by platinum-based chemotherapy, the relapse rate in ovarian cancer is high and many patients will recur within 6 months of completing platinum based treatment. These patients may still require further chemotherapy despite being ...

journal_title：Cancer treatment reviews

authors： Pinato DJ,Graham J,Gabra H,Sharma R

更新日期：2013-04-01 00:00:00

abstract：:Fulvestrant is a selective estrogen receptor downregulator, behaving as a complete antagonist. It was initially approved, at a dose of 250 mg, to treat hormone dependant breast cancer in second line setting. However, a series of pharmacological and pre-clinical studies have suggested that a higher dose of 500 mg may b...

journal_title：Cancer treatment reviews

authors： Estévez L,Alvarez I,Tusquets I,Seguí MA,Muñoz M,Fernández Y,Lluch A

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Gastric cancer remains a major health problem worldwide. Treatment of advanced gastric cancer is controversial and there is no standard regimen for first- or second-line chemotherapy (CT). This review aims to give an overview of the hot topics concerning treatment, prognostic factors and new strategies in ad...

journal_title：Cancer treatment reviews

authors： Cervantes A,Roda D,Tarazona N,Roselló S,Pérez-Fidalgo JA

更新日期：2013-02-01 00:00:00

abstract：:Malignant Pleural Mesothelioma (MPM) is an aggressive tumour with poor prognosis and increasing incidence in industrialized countries because of the previous widespread exposure to asbestos fibres and to the long lag period from time of exposure and the diagnosis of the disease. MPM shows high refractoriety to systemi...

journal_title：Cancer treatment reviews

authors： Pasello G,Ceresoli GL,Favaretto A

更新日期：2013-02-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men. Overall survival is considered the best endpoint for clinical trials, but it is difficult to use in phase-2 studies. Although the reduction of PSA after cytotoxic chemotherapy has been identified as a valid surrogate for overall survival, it has not proven reliable for...

journal_title：Cancer treatment reviews

authors： Colloca G

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:Dysphagia is a debilitating complication in head and neck cancer patients (HNCPs) that may cause a high mortality rate for aspiration pneumonia. The aims of this paper were to summarize the normal swallowing mechanism focusing on its anatomo-physiology, to review the relevant literature in order to identify the...

journal_title：Cancer treatment reviews

authors： Russi EG,Corvò R,Merlotti A,Alterio D,Franco P,Pergolizzi S,De Sanctis V,Ruo Redda MG,Ricardi U,Paiar F,Bonomo P,Merlano MC,Zurlo V,Chiesa F,Sanguineti G,Bernier J

更新日期：2012-12-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the biggest cancer killer in the United States and worldwide. In 2011, there are estimated to be 221,130 new cases of lung cancer in the United States. Over a million people will die of lung cancer worldwide this year alone. When possible, surgery to remove the tumor is the best t...

journal_title：Cancer treatment reviews

authors： Tucker ZC,Laguna BA,Moon E,Singhal S

更新日期：2012-10-01 00:00:00

abstract：:Aflibercept, also known as vascular endothelial growth factor (VEGF)-Trap, is a recombinant, decoy receptor fusion protein, rationally designed to block angiogenesis by targeting not only all forms of VEGF-A, but also VEGF-B and placental growth factor. It inhibits VEGF-induced angiogenesis in preclinical models. In t...

journal_title：Cancer treatment reviews

authors： Gaya A,Tse V

更新日期：2012-08-01 00:00:00

abstract：:In cancer biology angiogenesis plays a vital role in tumour growth and its subsequent metastatic potential. By targeting the angiogenic process, a new treatment strategy was added in the clinician's therapeutic armamentarium. On the other hand, numerous classic cytotoxic agents are currently considered as potential an...

journal_title：Cancer treatment reviews

authors： Soultati A,Mountzios G,Avgerinou C,Papaxoinis G,Pectasides D,Dimopoulos MA,Papadimitriou C

更新日期：2012-08-01 00:00:00

abstract：:Chest wall breast cancer recurrence after mastectomy is a disease difficult to treat. Its incidence varies between 5% and 30% in different subset of patients. When possible, radical surgical therapy represents the main treatment approach, however when the disease progresses and/or treatments are not successful, ulcera...

journal_title：Cancer treatment reviews

authors： Sersa G,Cufer T,Paulin SM,Cemazar M,Snoj M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Different modalities of treatment in early laryngeal cancer lead to equivalent oncological outcomes. Hence this systematic review was undertaken to synthesise the key oncological outcomes following primary open partial laryngectomy for laryngeal cancer. METHODS:A systematic review of the English literature ...

journal_title：Cancer treatment reviews

authors： Thomas L,Drinnan M,Natesh B,Mehanna H,Jones T,Paleri V

更新日期：2012-05-01 00:00:00

abstract：:While chemotherapy has been the standard of care for patients with advanced non-small cell lung cancer (NSCLC), efforts have shifted toward evaluating novel targeted agents in an attempt to improve outcome. These targeted agents are directed toward key components in several signalling pathways such as vascular endothe...

journal_title：Cancer treatment reviews

authors： Belani CP,Goss G,Blumenschein G Jr

更新日期：2012-05-01 00:00:00

abstract：:Bone-seeking radionuclides, such as Sr-89, Sm-153, and Re-186, have been shown to have an effect on pain from bone metastasis in prostate cancer. The effect on bone pain in other cancer types, including breast cancer, remains unclear. The purpose of the study was to perform a systematic review of the use of radioisoto...

journal_title：Cancer treatment reviews

authors： Christensen MH,Petersen LJ

更新日期：2012-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most frequent and deadliest cancers worldwide. Liver transplantation, surgical resection or local ablation offer the best survival advantages but most patients either present when the tumor is in an advanced stage or the degree of underlying liver disease precludes these op...

journal_title：Cancer treatment reviews

authors： Meza-Junco J,Montano-Loza AJ,Liu DM,Sawyer MB,Bain VG,Ma M,Owen R

更新日期：2012-02-01 00:00:00

abstract：:Currently, platinum-based combination chemotherapy is the standard first-line chemotherapy for non-small-cell lung cancer (NSCLC). Historically, platinum-based chemotherapy has been recommended for up to six cycles even for responders, and second-line chemotherapy has been considered when disease progression is confir...

journal_title：Cancer treatment reviews

authors： Kim YH,Mishima M

更新日期：2011-11-01 00:00:00

abstract：:Single-fraction stereotactic radiosurgery (SRS) and hypofractionated stereotactic radiotherapy (SRT) are radiation planning and delivery techniques used for the treatment of intracranial and spine/spinal cord tumors and targets. For cranial SRS and SRT, critical normal tissues/structures include the brainstem, cranial...

journal_title：Cancer treatment reviews

authors： Milano MT,Usuki KY,Walter KA,Clark D,Schell MC

更新日期：2011-11-01 00:00:00

abstract：:Neoadjuvant chemotherapy (NAC) for breast cancer is evolving and subsequent adjuvant systemic treatment is mainly based on the presence of the Estrogen (ER) receptor, Progesterone (PR) receptor and Human Epidermal growth factor Receptor 2 (HER2) status on the core needle biopsy prior to treatment. It is not well known...

journal_title：Cancer treatment reviews

authors： van de Ven S,Smit VT,Dekker TJ,Nortier JW,Kroep JR

更新日期：2011-10-01 00:00:00

abstract：:Sarcomas of the head and neck region are a rare group of tumors in children and present challenges with regard to evaluation and treatment. Rhabdomyosarcomas are the most common sarcomas of the head and neck in children. Presence of metastases and complete surgical resectability continue to be the most relevant clinic...

journal_title：Cancer treatment reviews

authors： Huh WW,Fitzgerald N,Mahajan A,Sturgis EM,Beverly Raney R,Anderson PM

更新日期：2011-10-01 00:00:00

abstract：:Metastatic malignant melanoma remains one of the most dreaded skin cancers worldwide. Numerous factors contribute to its resistance to hosts of treatment regimes and despite significant scientific advances over the last decade in the field of chemotherapeutics and melanocytic targets, there still remains the need for ...

journal_title：Cancer treatment reviews

authors： Davids LM,Kleemann B

更新日期：2011-10-01 00:00:00

abstract：:The first-generation epidermal growth factor receptor tyrosine kinase inhibitors erlotinib and gefitinib have been incorporated into treatment paradigms for patients with advanced non-small cell lung cancer. These agents are particularly effective in a subset of patients whose tumors harbor activating epidermal growth...

journal_title：Cancer treatment reviews

authors： Giaccone G,Wang Y

更新日期：2011-10-01 00:00:00

abstract：:When focusing on heart disease, most available studies split the two different parts of the adjuvant treatment, i.e., systemic therapies and radiation therapy, making it difficult to implement efficient strategies for preventing treatment-induced cardiac toxicity. This paper reviews the current understanding of treatm...

journal_title：Cancer treatment reviews

authors： Chargari C,Kirov KM,Bollet MA,Magné N,Védrine L,Cremades S,Beuzeboc P,Fourquet A,Kirova YM

更新日期：2011-06-01 00:00:00

abstract：:Hepatocellular carcinoma (hepatocellular carcinoma, HCC) is the commonest primary liver cancer (80-90%) and represents the leading cause of cancer-related death, after lung and stomach cancer. The process of neoplastic transformation proceeds through the accumulation of mutations in the genes governing cell proliferat...

journal_title：Cancer treatment reviews

authors： Faloppi L,Scartozzi M,Maccaroni E,Di Pietro Paolo M,Berardi R,Del Prete M,Cascinu S

更新日期：2011-05-01 00:00:00

abstract：:Although surgery provides excellent control for localized prostate cancer, pathologic examination of more than one-third of specimens will reveal positive surgical margins, seminal vesicle invasion, and/or extracapsular extension, thus putting these patients at increased risk of cancer recurrence. "Adjuvant" radiother...

journal_title：Cancer treatment reviews

authors： Raldow A,Hamstra DA,Kim SN,Yu JB

更新日期：2011-04-01 00:00:00

abstract：:Patients diagnosed with advanced gastrointestinal stromal tumor (GIST) are currently treated with oral tyrosine kinase inhibitors (TKIs). Imatinib mesylate is the standard first-line treatment, and sunitinib malate is administered second-line for patients who are intolerant or progress on imatinib. Imatinib has recent...

journal_title：Cancer treatment reviews

authors： Joensuu H,Trent JC,Reichardt P

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:To conduct a systematic review and meta-analysis of all phase III randomized controlled trials comparing efficacy of early versus late first-line or initial treatments for cancer. METHODS:A comprehensive literature search of MEDLINE and Cochrane library databases was performed (1966-2008). Data was extracted a...

journal_title：Cancer treatment reviews

authors： Mhaskar AR,Quinn G,Vadaparampil S,Djulbegovic B,Gwede CK,Kumar A

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Treatment of relapsed hematological malignancies after an allogeneic peripheral blood stem cell transplant (SCT) is challenging. Donor lymphocyte infusion (DLI) from the stem cell donor is an attractive clinical option to salvage this group of patients. METHODS:We reviewed the important studies looking at d...

journal_title：Cancer treatment reviews

authors： Deol A,Lum LG

更新日期：2010-11-01 00:00:00

abstract：:Capecitabine is an orally administered fluoropyrimidine carbamate which has been developed as a prodrug of 5-FU with the goal to improve its tolerability and intratumoral drug concentration. The review aims to provide an evidence-based update of clinical trials investigating the clinical efficacy, adverse-event profil...

journal_title：Cancer treatment reviews

authors： Silvestris N,Maiello E,De Vita F,Cinieri S,Santini D,Russo A,Tommasi S,Azzariti A,Numico G,Pisconti S,Petriella D,Lorusso V,Millaku A,Colucci G

更新日期：2010-11-01 00:00:00

abstract：:Arc therapies have gained widespread clinical interest in radiation oncology over the past decade. Arc therapies have several potential advantages over standard techniques such as intensity-modulated radiation therapy, with implications for patients, administrators, and oncologists. This review focuses on the rational...

journal_title：Cancer treatment reviews

authors： Palma DA,Verbakel WF,Otto K,Senan S

更新日期：2010-08-01 00:00:00

abstract：:During the last decade, important progress has been made in the surgical treatment of malignant liver tumors in children. For hepatoblastoma, there is a general consensus for combining surgical resection with neoadjuvant (and adjuvant) chemotherapy. Long-term disease-free survival of around 85-90% can be achieved for ...

journal_title：Cancer treatment reviews

authors： Otte JB

更新日期：2010-06-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of cells with the phenotype of activated Langerhans cells. The diagnosis of LCH is often delayed or missed. Many questions about LCH remain to be answered, including whether it is caused by a malignancy or by immune dysregulation. Data from the early...

journal_title：Cancer treatment reviews

authors： Abla O,Egeler RM,Weitzman S

更新日期：2010-06-01 00:00:00

abstract：:Due to advances in chemotherapy and supportive care, greater than 70% of patients with childhood cancer will survive 5 years. However, there are long-term physiological and psychological sequelae of these treatments that may not manifest until pediatric survivors are into adulthood. Various studies done in the long-te...

journal_title：Cancer treatment reviews

authors： Prasad PK,Bowles T,Friedman DL

更新日期：2010-06-01 00:00:00

abstract：:Prostate cancer is one of the leading causes of cancer related death in men, and remains incurable in the metastatic setting. Despite the initial response to androgen deprivation, the disease gradually progresses to a hormone-refractory state due to cumulative genetic alterations in tumour cells or the microenvironmen...

journal_title：Cancer treatment reviews

authors： Stavridi F,Karapanagiotou EM,Syrigos KN

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:Cancer is increasingly being viewed as a chronic illness requiring long-term management, and there is a growing need for evidence-based rehabilitation interventions for cancer survivors. Previous reviews have evaluated the benefits of exercise interventions for patients undergoing cancer treatment and long...

journal_title：Cancer treatment reviews

authors： Spence RR,Heesch KC,Brown WJ

更新日期：2010-04-01 00:00:00

abstract：:Resistance to tyrosine-kinase inhibitors remains an open issue in the treatment of patients with gastrointestinal stromal tumors. The complex biology of disease in the multi-resistant setting has led a progressively growing urgency and interest in development combined or integrated therapies. This mini-review outlines...

journal_title：Cancer treatment reviews

authors： Pantaleo MA,Nannini M,Di Battista M,Catena F,Biasco G

更新日期：2010-02-01 00:00:00

abstract：:Metastatic breast cancer is ultimately an incurable disease, although recent data have shown that its incidence is decreasing and that patients with metastatic breast cancer live longer. This improvement in survival seems to be linked with the introduction of new therapeutic agents, novel combinations of existing ther...

journal_title：Cancer treatment reviews

authors： Fernández Y,Cueva J,Palomo AG,Ramos M,de Juan A,Calvo L,García-Mata J,García-Teijido P,Peláez I,García-Estévez L

更新日期：2010-02-01 00:00:00

abstract：:Aberrant activation of HER2 through overexpression has been shown to play an important role in some breast cancers. Therapies against this receptor including the monoclonal antibody, trastuzumab, or the small tyrosine kinase inhibitor, lapatinib have shown to improve the prognosis of such patients. Despite overexpress...

journal_title：Cancer treatment reviews

authors： Ocaña A,Amir E

更新日期：2009-12-01 00:00:00

abstract：:Whereas first-line chemotherapy (CT) with single-agent gemcitabine or gemcitabine-based combinations provides a proven benefit in patients with locally advanced or metastatic pancreatic cancer (PC), the role of salvage CT after gemcitabine-failure is not well-established and to date no regimen has emerged as preferred...

journal_title：Cancer treatment reviews

authors： Custodio A,Puente J,Sastre J,Díaz-Rubio E

更新日期：2009-12-01 00:00:00

abstract：:Cancer cells exhibit deregulation in multiple cellular signaling pathways. Therefore, treatments using specific agents that target only one pathway usually fail in cancer therapy. The combination treatments using chemotherapeutic agents with distinct molecular mechanisms are considered more promising for higher effica...

journal_title：Cancer treatment reviews

authors： Sarkar FH,Li Y

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:To synthesize the evidence from randomized controlled trials concerning systemic treatment regimens for patients with cancer of unknown primary site (CUP). DATA SOURCES:PubMed and the Cochrane Library Central Registry of Controlled Trials. REVIEW METHODS:We retrieved all randomized controlled trials compar...

journal_title：Cancer treatment reviews

authors： Golfinopoulos V,Pentheroudakis G,Salanti G,Nearchou AD,Ioannidis JP,Pavlidis N

更新日期：2009-11-01 00:00:00

abstract：:Since its first regulatory approval more than 10 years ago, oncologists have gained wide experience in using the oral fluoropyrimidine, capecitabine, as monotherapy or in combination with other agents and the body of evidence supporting these approaches continues to grow. Alongside this increasing experience has been ...

journal_title：Cancer treatment reviews

authors： Barrett-Lee P,Bidard FC,Pierga JY

更新日期：2009-11-01 00:00:00